| Date | Opponent | Site | Time | Result | Comments/Results |
|---|---|---|---|---|---|
| September 2 | Urbana | Home | 7:00 p.m. | W, 42-17 | Community Night; Donaldson breaks rushing record/1-0 overall, 0-0 NCACBOX SCORES / Highlights |
| September 9 | Heidelberg | Away | 7:30 p.m. | W, 33-14 | Tigers take to the air on DeGraffinreed's career night/2-0 overall, 0-0 NCAC BOX SCORES / Highlights |
| September 16 | Alma | Home | 1:30 p.m. | W, 39-14 | Walker breaks Wittenberg points by kicking record/3-0 overall, 0-0 NCAC BOX SCORES / Highlights |
| September 23 | Wabash | Away | 2:30 p.m. EDT | W, 41-10 | Tigers win lightning-delayed NCAC opener/4-0 overall, 1-0 NCACPre-game Notes / BOX SCORES / Highlights |
| September 30 | Allegheny | Away | 1:30 p.m. | W, 35-21 | Donaldson breaks NCAC career rushing record/5-0, 2-0 NCAC Pre-game Notes / BOX SCORES / Highlights |
| October 7 | Denison | Home | 1:30 p.m. | W, 62-7 | Eight players score touchdowns/6-0, 3-0 NCAC Pre-game Notes / BOX SCORES / Highlights |
| October 14 | Wooster | Home | 1:30 p.m. | W, 42-26 | Donaldson runs wild for 262 yards and four TDs/7-0, 4-0 NCAC Pre-game Notes / BOX SCORES / Highlights |
| October 21 | Ohio Wesleyan | Away | 1:30 p.m. | W, 37-7 | Balanced offense includes return of Gary Henson (105 yards) and steady Donaldson (147 yards)/8-0, 5-0 NCAC Pre-game Notes / BOX SCORES / Highlights |
| October 28 | Hiram | Home | 1:30 p.m. | W, 66-0 | Homecoming/Athletics Hall of Honor Tigers clinch at least a share of a fourth straight NCAC title/9-0, 6-0 NCAC Pre-game Notes / BOX SCORES / Highlights |
| November 4 | Earlham | Home | 1 p.m. | W, 37-14 | Coach Fincham becomes fastest to 50 wins in school history/10-0, 7-0 NCAC Pre-game Notes / BOX SCORES / Highlights |
| November 18 | Aurora | Home | Noon | W, 31-20 | Division III NCAA Tournament - Third straight year Wittenberg opened playoffs with home victory/11-0, 7-0 NCAC BOX SCORES / Highlights |
| November 25 | Hanover | Home | Noon | W, 32-21 | Tigers rally in fourth quarter on the back of Casey Donaldson, who scored five touchdowns/12-0, 7-0 NCAC Pre-game Notes / BOX SCORES / Highlights |
| December 2 | Mount Union | Away | Noon | L, 15-32 | Tigers dreams of a title grounded by three costly turnovers in NCAA Quarterfinal match-up with nation's No. 1 team/12-1, 7-0 NCAC (Champions) Pre-game Notes / BOX SCORES / Highlights |