| Date | Day | Opponent | Site | Time | Result | Comments/Record |
| Aug. 31 | Friday | vs. DePauw | Away | | W, 4-1 (25-30, 30-26, 30-22, 30-26) | Mt. St. Joseph Tournament; Teresa Murphy leads Tigers with 19 kills, Monica McDonald adds 13/1-0, 0-0 NCAC |
| Aug. 31 | Friday | vs. Southern Virginia | Away | | W, 3-0 (30-28, 30-21, 30-19) | Mt. St. Joseph Tournament; Teresa Murphy leads Tigers again with 12 kills/2-0, 0-0 NCAC |
| Sept. 1 | Saturday | vs. Ohio Northern | Away | | W, 3-2 (30-28, 17-30, 30-32, 30-26, 15-10) | Mt. St. Joseph Tournament; Tigers capture third straight win over Ohio Athletic Conference champion and ninth-ranked team in the country as Teresa Murphy, Monica McDonald and Sara Muzi combine for 54 kills/3-0, 0-0 NCAC |
| Sept. 1 | Saturday | vs. Mt. St. Joseph | Away | | L, 1-3 (18-30, 21-30, 30-25, 21-30) | Mt. St. Joseph Tournament; Tigers lose fifth straight match against Mt. St. Joseph, ninth-ranked team in nation, despite 26 kills between Teresa Murphy and Sara Muzi/3-1, 0-0 NCAC |
| Sept. 7 | Friday | Wheaton | Away | | W, 3-0 (30-11, 30-20, 30-23) | Elmhurst (Ill.) Tournament; Tigers are paced by Monica McDonald's 16 kills and three aces/4-1, 0-0 NCAC |
| Sept. 7 | Friday | Lake Forest | Away | | W, 3-0 (30-21, 30-11, 31-29) | Elmhurst (Ill.) Tournament; Brittany Baume powers Tigers to another win with 16 kills/5-1, 0-0 NCAC |
| Sept. 8 | Saturday | Illinois Wesleyan | Away | | W, 3-0 (30-26, 30-25, 30-27) | Elmhurst (Ill.) Tournament; Brittany Baume and Monica McDonald kill 10 apiece/6-1, 0-0 NCAC |
| Sept. 8 | Saturday | Elmhurst | Away | | L, 1-3 (22-30, 31-29, 23-30, 19-30) | Elmhurst (Ill.) Tournament championship match goes against Tigers/6-2, 0-0 NCAC |
| Sept. 14 | Friday | Cedarville | Home | 7 p.m. | W, 3-0 (30-20, 30-22, 30-27) | Tigers collect victory behind Teresa Murphy's 13 kills; Connie Surowicz gets 200th career victory at Wittenberg/7-2, 0-0 NCAC |
| Sept. 21 | Friday | Walsh | Away | 7 p.m. | L, 1-3 (30-26, 24-30, 27-30, 23-30) | Monica McDonald leads Tigers with 22 kills and .317 attack percentage but Tigers can't overcome NAIA power Walsh/7-3, 0-0 NCAC |
| Sept. 22 | Saturday | Hiram | Away | 11 a.m. | W, 3-0 (30-6, 30-14, 30-18) | NCAC opener at Wooster; Shelli Habegger distributes 36 assists and Teresa Murphy leads offense with 13 kills/8-3, 1-0 NCAC |
| Sept. 22 | Saturday | Wooster | Away |
1 p.m. | W, 3-0 (31-29, 30-16, 30-20) | Monica McDonald pounds 18 kills and finishes with .316 attack percentage; Brittany Baume adds four aces and Teresa Murphy contributes 10 kills and 13 digs/9-3, 2-0 NCAC |
| Sept. 25 | Tuesday | Earlham | Away | 6 p.m. | W, 3-0 (30-16, 30-11, 30-23) | Rescheduled from Sept. 12 due to national tragedies/10-3, 3-0 NCAC |
| Sept. 28 | Friday | Case Western Reserve | Home | 2:30 p.m. | W, 3-0 (30-17, 30-20, 30-19) | Wittenberg Tournament; Tigers capture straight set win to open home tourney behind 15 kills by Monica McDonald and 13 by Teresa Murphy |
| Sept. 28 | Saturday | Ohio Northern | Home
| 7:30 p.m. | W, 3-2 (30-28, 27-30, 24-30, 32-30, 15-12) | Wittenberg Tournament; Tigers rally for victory by pulling out tough Games 4 and 5; Shelli Habegger distributes 42 assists and Monica McDonald and Teresa Murphy combine for 55 kills between them/12-3, 3-0 NCAC |
| Sept. 29 | Saturday | Muskingum | Home
| 10 a.m. | W, 3-1 (30-21, 28-30, 30-24, 30-23) | Wittenberg Tournament/13-3, 3-0 NCAC |
| Sept. 29 | Saturday | Elmhurst | Home
| 3 p.m. | L, 2-3 (21-30, 28-30, 30-20, 30-28, 15-9) | Wittenberg Tournament; Monica McDonald and Teresa Murphy earn all-tournament team honors/13-4, 3-0 NCAC |
| Oct. 6 | Saturday | Allegheny | Away
| 11 a.m. | W, 3-0 (30-26, 30-22, 30-21) | Freshman duo of Sarah Yuskewich and Monica McDonald team up for 37 assists and 25 kills respectively/14-4, 4-0 NCAC |
| Oct. 6 | Saturday | Denison | Away
| 1 p.m. | W, 3-2 (30-24, 38-40, 30-28, 23-30, 15-10) | Closest NCAC match in several years for Wittenberg decided on the strength of Monica McDonald's 36 kills/15-4, 5-0 NCAC |
| Oct. 10 | Wednesday | Ohio Wesleyan | Home | 7
p.m. | W, 3-0 (30-18, 30-18, 30-22) | Game to be televised on Time Warner Cable on Thursday, Oct. 11 at 10 p.m., Sunday, Oct. 14 at 4 p.m. and Monday, Oct. 15 at 9:30 p.m.; Teresa Murphy finishes with 13 kills and 12 digs, Tiffany Keller adds 11 kills and 13 digs/16-4, 6-0 NCAC |
| Oct. 12 | Friday | Thomas More | Home | 2:30 p.m. | W, 3-0 (30-18, 30-24, 30-22) | Wittenberg National Invitational Monica McDonald records a .294 attack percentage and pounds 13 kills while Teresa Murphy leads stellar defensive effort with 24 digs/17-4, 6-0 NCAC |
| Oct. 12 | Friday | Wisconsin-Whitewater | Home | 7:30 p.m. | L, 0-3 (27-30, 21-30, 18-30) | Wittenberg National Invitational Tigers can't keep pace with nation's top-ranked team despite 12 kills by Monica McDonald and 13 more from Tiffany Keller/17-5, 6-0 NCAC |
| Oct. 13 | Saturday | Juniata | Home | 10 a.m. | L, 0-3 (26-30, 20-30, 21-30) | Wittenberg National Invitational Tigers fall to fifth-ranked team in the nation despite 14 kills by Monica McDonald and an attack percentage of .323/17-6, 6-0 NCAC |
| Oct. 13 | Saturday | Mt. St. Joseph | Home | 3 p.m. | L, 1-3 (28-30, 23-30, 30-26, 21-30) | Wittenberg National Invitational Tigers fall for third straight time to ranked opponent and sixth straight time to Mt. St. Joseph despite 19 kills for Monica McDonald and Sarah Yuskewich's 57 assists/17-7, 6-0 NCAC |
| Oct. 18 | Thursday | Thomas More | Away | 7 p.m. | W, 3-2 (30-18, 26-30, 26-30, 30-18, 15-8) | 18-7, 6-0 NCAC |
| Oct. 20 | Saturday | Kenyon | Home | 11 a.m. | W, 3-0 (30-17, 30-13, 30-18) | Tigers dominate another NCAC opponent behind 28 assists for Sarah Yuskewich and 14 kills for Lindsay Nelson/19-7, 7-0 NCAC |
| Oct. 20 | Saturday | Oberlin | Home | 3 p.m. | W, 3-0 (30-10, 30-9, 30-17) | Tigers wrap up fourth straight perfect 8-0 NCAC regular season behind 10 kills by Teresa Murphy and 28 assists by Sarah Yuskewich/20-7, 8-0 NCAC |
| Oct. 26 | Friday | Texas Lutheran | Away
| | W, 3-0 (30-20, 30-23, 30-25) | Trinity (Tex.) Tournament; Tigers win behind Sarah Yuskewich's 36 assists and Monica McDonald's 15 kills/21-7, 8-0 NCAC |
| Oct. 26 | Friday | Juniata | Away | | W, 3-2 (30-23, 32-30, 28-30, 26-30, 15-12) | Trinity (Tex.) Tournament; Tigers defeat No. 2 team in the country in dramatic five-setter; Monica McDonald shows way on offense with 32 kills, while Teresa Murphy stands out on defense with 21 digs/22-7, 8-0 NCAC |
| Oct. 27 | Saturday | Wartburg | Away | | W, 3-2 (27-30, 33-31, 25-30, 30-24, 15-13) | Trinity (Tex.) Tournament; Tigers come from behind to defeat No. 3 team in the country in dramatic five-setter as Monica McDonald pounds 26 kills and Sarah Yuskewich distributes 73 assists/23-7, 8-0 NCAC |
| Oct. 27 | Saturday | Trinity | Away | | L, 2-3 (30-26, 16-30, 24-30, 30-28, 12-15) | Trinity (Tex.) Tournament; Tigers fall to No. 5 ranked team in the nation despite several fine performances, including Monica McDonald's 21 kills and Michelle Emming's 19 digs/23-8, 8-0 NCAC |
| Oct. 30 | Tuesday | Oberlin | Home | 7 p.m. | W, 3-0 (30-9, 30-22, 30-9) | NCAC Quarterfinals; No. 1 seed Wittenberg defeats No. 8 seed Oberlin handily behind Monica McDonald's 11 kills, Teresa Murphy's 13 kills and Michelle Emming's five aces/24-8, 8-0 NCAC |
| Nov. 2 | Friday | Wooster | Home | 8 p.m. | W, 3-0 (30-23, 30-23, 30-22) | NCAC Semifinals; No. 1 seed Wittenberg def. No. 4 seed Wooster behind Monica McDonald's 17 kills and Sarah Yuskewich's 48 assists, also 24 digs between Michelle Emming and Teresa Murphy/25-8, 8-0 NCAC |
| Nov. 3 | Saturday | Denison | Home | 2 p.m. | W, 3-0 (30-23, 30-17, 30-15) | NCAC Finals; No. 1 seed Wittenberg def. No. 2 seed Denison behind the brilliant play of Tournament MVP Tiffany Keller and all-tournament choices Teresa Murphy and Monica McDonald; Tigers win record-breaking fifth straight NCAC tournament title/26-8, 8-0 NCAC |
| Nov. 9 | Friday | Ohio Northern | Away | 5 p.m. | L, 1-3 (28-30, 25-30, 30-28, 23-30) | NCAA Tournament; Great Lakes Regional at Mt. St. Joseph - Tigers receive first-round bye but fall in regional semifinals despite 25 kills by Monica McDonald/26-9, 8-0 NCAC |