One of the university's most beautiful buildings, Weaver Chapel contains spectacular stained glass windows that have been featured in National Geographic. In each window, the graphic portion consists of solid lead, and glass is used only as a background. The 24 panels at the front entrance depict the history of Wittenberg from Luther's Wittenberg in Germany to the present institution. The last pane displays Wittenberg's Seal and motto, "Having Light We Pass It on to Others." Outside the chapel, the statues on the 212-foot tower represent Gottfried Leibnitz, John Milton, Johann Sebastian Bach, St. Augustine, Martin Luther and St. Paul of Tarsus.

During the academic year, the university pastors conduct a Lutheran service on Sunday mornings in the chapel. Catholic Mass is offered Sunday nights, and weekday chapel occurs twice a week on Tuesday and Thursday mornings. Religious opportunities and organizations are available for students from various traditions, including Weaver Chapel Association, Habitat for Humanity, Athletes for Christ, the Newman Club, The Jewish Student Group and Primetime. Springfield also has a synagogue, and local churches encourage students to attend worship. Guest lectures, concerts and weddings are also held in Weaver Chapel throughout each year.